The effect of exposure to mupirocin on the survival and recovery of sensitive Staphylococcus aureus strains
نویسندگان
چکیده
A significant percentage survival, representing a large number of viable cells, can occur in a Staphylococcus aureus population exposed to concentrations of mupirocin up to 1,000 times the minimum inhibitory concentration. An elevated ratio of minimum inhibitory to minimum bactericidal concentration of mupirocin with staphylococci was recorded. Staphylococci which survive exposure to mupirocin may be less sensitive to the subsequent bactericidal action of the antibiotic. The observations may explain the re-colonisation with staphylococci seen in some studies.
منابع مشابه
شناسایی مقاومت به موپیروسین در سویههای استافیلوکوکوس اورئوس جدا شده از بیماران 4 بیمارستان دانشگاهی تهران با روش PCR
Introduction: Mupirocin, an inhibitor of bacterial isoleucyl-tRNA synthetase, has used to treat staphylococcal skin infections as well as to eliminate nasal carriage of Staphylococcus aureus. Mupirocin resistant Staphylococcus aureus strains are seen worldwide but there is no report from Iran. In the present study, by using phenotyping methods (disk diffusion and E-test) in combination with P...
متن کاملRisk Factors of Nasal Carriage of Methicillin-Resistant Staphylococcus Aureus and its Antibiotic Susceptibility Pattern in Namazi hospital Healthcare Workers in Shiraz, Iran
Background & Aims: Methicillin-resistant Staphylococcus aureus (MRSA) is a major nosocomial pathogen worldwide. The aim of this study was to determine the risk factors of nasal carriage of MRSA and its antibiotic susceptibility pattern among healthcare workers at Namazi Hospital (Shiraz-Iran) Methods: In a cross-sectional study from July to November 2006, nasal swabs were taken from 600 stratif...
متن کاملبررسی فنوتیپ و ژنوتیپ مقاومت به موپیروسین در بین استافیلوکوک های مقاوم و حساس به متی سیلین جدا شده از عفونت های بیمارستانی
Background and purpose: Mupirocin is a topical antibiotic. This antibiotic can inhibit most of gram-positive cocci. Shortly after consuming the antibiotic mupirocin, resistance has emerged. The main purpose of this study was to determine mupirocin resistance in Staphylococcus strains isolated from nosocomial infections in the city of Arak. Material and Methods: A total of 150 Staphylococcus...
متن کاملSusceptibility To Vancomycin In Staphylococcus Aureus Isolated From Patients Of Four University-Affiliated Hospitals In Tehran
Background and Objective: Vancomycin is frequently the antibiotic of choice for the treatment of infections caused by methicillin-resistant Staphylococcus aureus (MRSA). For the last years, the incidence of vancomycin-intermediate S. aureus (VISA) and vancomycin-resistant S. aureus (VRSA) has been increased in various parts of the world. The present study ...
متن کاملThe Effect of Thyme (Thymus vulgaris) Extract on the Expression of norA Efflux Pump Gene in Clinical Strains of Staphylococcus aureus
The NorA efflux pump considered as one of the contributors to antibiotic resistance in Staphylococcus aureus strains. One of the challenges of the researchers is finding natural plant compounds with the ability to inhibit the pumps. The aim of this study was to investigate the inhibitory effect of thyme (Thymus vulgaris) extract on NorA efflux pump in ciprofloxacin-resistant strains of S. aureu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- The Ulster Medical Journal
دوره 57 شماره
صفحات -
تاریخ انتشار 1988